Since the outbreak of COVID-19, anti-epidemic design has once again become a hot topic in the field of design at home and abroad. In the history of the design of human--s fight against the epidemic, different space planning and product design have helped people to fight against the epidemic in different degrees. Epidemic prevention has become one of the important driving forces of human society--s design practice. The designs for epidemic situation should start from the top-level perspective and be guided by HiAP. Human-centered innovative design thinking and harmonious design concept of production, life and ecology are used to accelerate the integration innovation of“design”and“industry + life + environment”, so as to build a new overall design pattern for epidemic prevention and control. In combination with the design culture with oriental wisdom, a beautiful future of harmonious coexistence between man and nature, man and society, and man and man will be built to contribute to the building of a community with shared future for mankind.