The work aims to analyze and process the users -- preferences, status and environmental information by artificial intelligence (AI) technology and display more reasonable driving suggestions and layout of vehicle-mounted human-computer interaction interface more in line with users' habits in the vehicle-mounted human-computer interaction interface, so as to provide users with more natural human-computer interaction experience. The development status of vehicle-mounted human-computer interaction interface and AI technology was analyzed and AI technology was introduced into the vehicle-mounted human-computer interaction interface. Quantitative and qualitative researches such as questionnaire and driving behavior observations were carried on users to analyze driving behaviors and driving preferences and understand the users-- requirements on interaction patterns and interactive interface display forms. Then, an interactive design strategy for vehicle-mounted human-computer interaction interfaces based on these requirements and characteristics of AI technology was put forward. Based on the characteristics of AI technology and the results of user research, the interactive design strategy of vehicle-mounted human-computer interaction interface has been proposed-the vehicle- mounted human-computer interaction interface should be optimized in hierarchical design, layout design, and information presentation to reduce the occupation of user attention resources. According to this strategy, the AI and vehicle-mounted human-computer interaction interface should be naturally combined, and the vehicle-mounted human-computer interaction interface should be dynamicallyadjusted in line with users-- preferences and event priorities.