Due to the spatial particularity of VR image, the work aims to solve the problem of information redundancy in viewing space by designing spatial visual guidance, and helps to make up for weaknesses of not too many edit points and less movement available of VR image. By analyzing the characteristics of VR image and the particularities of visual guidance, and combining with the theories of spatial working memory and visual search in psychology, the spatial visual guidance in VR image are designed. The creation of VR images can achieve effective visual guidance by increasing blank space, setting target association and controlling scene element recognition, so as to mobilize the audience’s vision, establish the association between visual objectives and psychological expectations, and then achieve the purpose of creating atmosphere and promoting narrative. The design of VR image spatial vision guidance optimizes the visual search efficiency of the audience, enhances the speed of the audience to receive information, and improves the creation space of VR image.