By comparing the development of cultural resources and cultural creativity (hereinafter referred to as cultural and creative) products industry in Beijing-Tianjin region, this paper analyzes the development gap and cultural resource differences between the two places, excavates the cultural gene value and application methods in cultural and creative products in Beijing-Tianjin region, and seeks theoretical basis and guiding methods for the scientific, systematic and high-quality development of cultural and creative industry in Beijing-Tianjin region. This paper analyzes and exemplifies the regional cultural resources in Beijing and Tianjin through the theory of cultural genes, combs and positions some resources that can be transformed into cultural and creative development with the help of the stratification and classification method of cultural genes, and establishes the path of cultural and creative transformation and resource development. Starting from the screening and application of main genes, attachment genes and mixed genes, we should optimize the development structure of cultural and creative industries, improve the quality of cultural and creative products in Beijing-Tianjin region, help the cultural and creative product industries in Beijing-Tianjin region clarify the cultural gene level, and protect, inherit and innovate the regional characteristic culture.