The expression forms and explanation clues of knowledge content are diverse, and everyone's learning needs and learning paths are different. but constrained by the real space conditions, traditional museums usually can only present their contents in a relatively fixed form. Virtual museums can break through the limitations of traditional exhibition conditions, and reorganize the composition of space in real time to create a dynamic exhibition space and tour routes for each user. Among them, the fixed exhibition hall and exhibition wall can be transformed into a dynamic knowledge network for free exploration and learning, which makes the knowledge content more suitable for learning. In relevant research and design applications, the thinking inertia of real space forms or other media forms should be excluded as far as possible, and research and design innovation based on the characteristics of knowledge content and around users' cognitive laws and learning needs should be carried out. Based on the theory of cognitive knowledge representation, this paper combines the network representation form of knowledge content with the organization and browsing clues of exhibition content in virtual space, and designs various dynamic spatial composition relationship of virtual museums to provide reference for relevant research and application.