The work aims to explore the influence of Chinese book design in the period of the late Qing Dynasty and the Republic of China on the innovation of typeface in the intelligent era, focusing on the integration of continuation and innovation of the traditional vein. By analyzing the characteristics of Chinese and Western hybridization of book design in the period of the late Qing Dynasty and the Republic of China, the vein of traditional Chinese printing industry is clarified, and its inspiration to contemporary typography is revealed and projected to new situations, new industries, and new media. Firstly, the changes in book design in the period of the late Qing Dynasty and the Republic of China are investigated, including the transformation of layout, the popularization of lead printing technology and the change of cultural concepts, as well as its far-reaching impact on the social and cultural life of the time. Secondly, the evolution of typeface design in the intelligent era is analyzed, and the balance between retro and innovation, as well as the embodiment of traditional veins in contemporary typography is discussed. The pluralistic coexistence of book design in the period of the late Qing Dynasty and the Republic of China and the characteristics of Chinese and Western hybridization provide an important inspiration for the innovation of typeface in the intelligent era. Traditional book design is not only a cultural heritage, but also a source of inspiration for contemporary typography. The re-examination of the traditional vein and the combination of contemporary technology will promote the development of typeface design in the intelligent era and realize the organic fusion of tradition and modernity.