The work aims to investigate the disciplinary path and main issues in the Sinicization of design science through a historical review of the development of design science in China. The methods of literature review and theoretical analysis are used to discuss the exploration and path of the Sinicization of design science since the 1950s. Combined with the background of European and American design research, horizontal connections and comparisons are carried out to reveal the connections and contextual differences in the communication of relevant theories. In the development process of design science in China, the field of engineering design has played an important role in promoting the scientific direction of design research. The qualitative method of art + design has given way to the scientific method of technology + design in design research. The improvement of China's design discipline system not only changes the previous separation between design scientific research and design practice changed, but also presents a shift from the introduction of theory to local innovation.