The circum-Taihu Lake region, centered around the Lake Tai, forms a saucer-shaped depression located in the southeast of the Yangtze River Delta. As the regional center in the northwest of the Taihu Plain, Changzhou is an important area with early recorded human development history. Since ancient times, it has been a crucial transportation hub along the canal. This paper reexamines the Changzhou region from the perspective of regional cultural landscapes, and understands it as a layered composite system integrating natural and human systems. Based on the research approach of cultural landscapes and with dynastic changes as a timeline, the development of various elements in the regional cultural landscape system of Changzhou is gradually uncovered from the perspectives of diachrony and synchrony. It explores the dynamic evolution of ancient human-land relationships. Analysis and interpretation are conducted from three aspects: temporal and spatial accumulation, spatial characteristics, and internal correlation factors, aiming to provide insights into cultural revival and high-quality urban-rural construction for cities along the Grand Canal within the strategic framework of the Grand Canal cultural belt and amidst the rapid urbanization process.