With the upsurge of cultural and creative products in recent years, various tourist attractions, museums, cultural and creative shops and other places have sold various kinds of cultural and creative products. At the same time, the rise of cultural and creative products has also brought the issue of product convergence, mainly in the lack of creative design, and similar design approaches. This paper explores the design of cultural products with regional cultural characteristics from the cultural core of cultural products, and studies the cultural connotation of cultural products from the "Ecology" of the concept of eco-museum, to activate the creative design through the native attribute of the ecological regional culture, hoping to excavate the local characteristic culture such as the craft with the wisdom crystallization of the regional people, the scene of People's labor, the daily necessities, the landscape environment with the region, etc. through the study of the living habits and customs of people in different regions, combine the modern science and technology and the esthetic orientation, expand the variety and connotation of cultural and creative products, promote the diversified development of cultural and creative products, reduce convergence, integrate the development of local regional economy with cultural and creative products with local people as the core, and form a good ecological culture cycle.