To enhance the interactive experience of the elderly using MOOCs, a research method for MOOC interaction design for the elderly based on Quality Function Deployment (QFD) and Structural Equation Modeling (SEM) is proposed. The process begins with user needs analysis to capture user needs. SEM is used to determine the weight of each user need. This is followed by Quality Function Deployment analysis, in which user needs are translated into design needs and SEM is used to obtain the relationship scores between user needs and design needs, thus a "user needs - design needs" quality house is constructed. Finally, design priority was determined and design strategies are formulated based on their priority, and the research findings are validated. Taking the interaction design of a "Traditional Chinese Medicine Health Knowledge" MOOC as an example, the results demonstrate that the proposed method can systematically analyze user needs and design needs, making the research results more objective and practical.